Traumatic Brain Injury Market: Epidemiology, Therapies, Companies, DelveInsight | veriNOS pharmaceuticals GmbH, Cellvation, Abalonex, Hope Biosciences

 


Some of the key facts of the Traumatic Brain Injury Market Report:

 

  • The global traumatic brain injury (TBI) market is projected to experience steady growth from 2025 to 2034, largely fueled by the development of innovative therapies. According to DelveInsight, there were approximately 4.3 million new TBI cases across the 7MM (United States, EU5, and Japan) in 2024, with numbers expected to rise throughout the forecast period. The United States reported the highest incidence, followed by Japan, Germany, France, and the United Kingdom.
  • In terms of market value, the U.S. led in 2024, with standard care generating around USD 1.12 billion. Current treatment approaches primarily involve off-label use of medications, including antidepressants, antiepileptics, antipsychotics, analgesics, antacids, and other symptom-relief drugs. Notably, 45–85% of TBI patients rely on psychotropic and pain medications, underscoring the high dependence on pharmacologic management.
  • Promising therapies, such as AKUUGO for chronic TBI, have received multiple regulatory designations recognizing their potential. Emerging treatments like ONP-002, CEVA101, OXE103 (Ghrelin), HB-AdMSCs, MR-301, NE3107a, and others are expected to transform the TBI treatment landscape and drive market expansion. Companies including Oragenics, Beyond Barriers Therapeutics, Noveome, and Neuroplast are exploring innovative delivery methods, such as intranasal and intrathecal administration.
  • There is increasing recognition of the need to address both psychiatric and non-neurological symptoms in TBI patients, particularly among females, and to carefully assess medication regimens to mitigate risks associated with polypharmacy. As research advances and new therapies gain approval, the TBI market is poised for significant growth over the next decade.
  • In 2024, the United States recorded an estimated 3,042,000 TBI cases, the highest among the 7MM. Within the EU4 and the UK, Germany had the highest number of cases, followed by France, while Spain reported the lowest. In the UK specifically, approximately 125,000 adults and 49,000 children were affected.
  • Regulatory progress has also enhanced diagnostic capabilities. On April 2, 2024, the FDA approved Abbott’s i-STAT TBI cartridge—a portable, whole-blood tool on the Alinity platform—providing lab-quality results in just 15 minutes to support concussion assessment and reduce unnecessary CT scans.
  • Key companies actively advancing TBI treatments include veriNOS Pharmaceuticals GmbH, Cellvation, Abalonex, and Hope Biosciences. Collectively, these emerging therapies and innovations are expected to reshape the TBI market landscape in the coming years.

Traumatic Brain Injury Overview

 

Traumatic brain injury (TBI) occurs when the brain sustains sudden damage due to a strong blow or jolt to the head. Common causes include motor vehicle accidents, falls, sports-related impacts, and physical assaults. The severity of TBI can range from mild concussions to serious injuries that result in long-term brain impairment. The immediate damage caused at the time of impact is known as the primary injury, which may affect a specific part of the brain or the brain as a whole. While skull fractures can occur, they are not always present. The brain may collide with the inner skull during trauma, causing bruising, bleeding, and damage to nerve fibers.

 

Symptoms of TBI vary according to injury severity and are typically categorized as mild, moderate, or severe. Mild TBI may involve brief loss of consciousness or no loss at all, with symptoms such as headache, dizziness, confusion, blurred vision, fatigue, ringing in the ears, sleep disturbances, mood or behavioral changes, and difficulties with memory or concentration.

 

Moderate to severe TBI symptoms are more pronounced and can include persistent or worsening headaches, repeated nausea or vomiting, seizures, inability to awaken, enlarged pupils, slurred speech, limb weakness or numbness, poor coordination, and heightened confusion or agitation.

 

Traumatic Brain Injury Market Outlook

 

Management of traumatic brain injury (TBI) typically involves a combination of medical care, rehabilitation, and supportive therapies designed to alleviate symptoms and promote recovery. Treatment strategies vary widely based on the injury’s severity, ranging from standard cognitive therapy sessions to more complex procedures, such as bilateral decompressive craniotomies. While clinical guidelines provide a framework for TBI care, they must be tailored to the individual patient’s specific needs and circumstances.

 

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